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Adjusts measured sodium for hyperglycaemic dilution using the Katz factor of 1.6 mmol/L and the Hillier factor of 2.4 mmol/L per 100 mg/dL of glucose above 100.
Sodium correction
Katz: corrected Na = Na + 0.016 x (glucose - 100); Hillier: corrected Na = Na + 0.024 x (glucose - 100), glucose in mg/dL
Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.
Hillier's 2.4 factor fits experimental data better, especially above 400 mg/dL glucose; Katz's 1.6 remains widely quoted.
Glucose is osmotically active and draws water out of cells, diluting the measured sodium concentration.