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Divides the AST-to-upper-limit ratio by platelet count to give the AST to platelet ratio index for liver fibrosis.
APRI
APRI = (AST / AST upper limit of normal) / platelet count (10^9/L) x 100; >1.5 suggests significant fibrosis, >2.0 cirrhosis
Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.
AST reference limits differ between laboratories, so using the local upper limit keeps the index comparable.
Chiefly in chronic hepatitis C, with reasonable performance also reported in hepatitis B and fatty liver disease.