Work out buffer preparation for pharmacy instantly with clear inputs, formula shown and shareable results.
Applies the Henderson-Hasselbalch equation to split a total buffer concentration into the acid and conjugate base needed for a target pH.
Henderson-Hasselbalch
pH = pKa + log([A-]/[HA]); so [A-]/[HA] = 10^(pH - pKa), and the two concentrations sum to the total buffer molarity
Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.
Outside that range one species dominates and the buffer resists pH change poorly.
Yes. Activity coefficients shift the effective pKa, so a prepared buffer should always be checked with a pH meter.