Work out hepatic dose adjustment instantly with clear inputs, formula shown and shareable results.
Applies the commonly used Child-Pugh based dose reductions for hepatically cleared drugs: no change in class A, about a quarter in class B and a half in class C.
Hepatic adjustment
Child-Pugh 5-6 (A) no change; 7-9 (B) reduce by about 25%; 10-15 (C) reduce by about 50% or avoid
Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.
There is no single measure of hepatic drug-metabolising capacity comparable to creatinine clearance.
No. Prodrugs needing hepatic activation may be less effective rather than more toxic in liver disease.