Hepatic Dose Adjustment Calculator

Work out hepatic dose adjustment instantly with clear inputs, formula shown and shareable results.

About Hepatic Dose Adjustment Calculator

Applies the commonly used Child-Pugh based dose reductions for hepatically cleared drugs: no change in class A, about a quarter in class B and a half in class C.

Formula

Hepatic adjustment

Child-Pugh 5-6 (A) no change; 7-9 (B) reduce by about 25%; 10-15 (C) reduce by about 50% or avoid

Worked example

With the default values below, Hepatic Dose Adjustment Calculator returns Suggested dose of 375.0. Change any input above and every figure here is recalculated in your browser.

Inputs used

Normal doseaccepts 0.1–10,000 mg: 500 mg
Child-Pugh scoreaccepts 5–15: 8

Results

Suggested dose: 375.0 mg
Reduction applied: 25%
Child-Pugh class: Class B
Caution: Monitor for accumulation and adjust on clinical response

Step by step

1Values used
2Hepatic adjustment
3Suggested dose= 375.0 mg
4Reduction applied= 25
5Child-Pugh class= Class B
6Caution= Monitor for accumulation and adjust on clinical response

Assumptions and limits

The result is derived only from the 2 inputs listed above. Anything not among them is not part of the calculation.
In particular, this calculator does not take inflation, tax, fees or charges or compounding frequency into account.
Figures are rounded for display to 1 decimal place, so totals built from several rounded parts can differ slightly from the unrounded arithmetic.
Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.

How these calculators are built and tested is described on the Methodology page. If a figure looks wrong, please report it.

Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.

Frequently Asked Questions

Why is hepatic dosing less precise than renal?

There is no single measure of hepatic drug-metabolising capacity comparable to creatinine clearance.

Does this apply to prodrugs?

No. Prodrugs needing hepatic activation may be less effective rather than more toxic in liver disease.