Hormone Replacement Dose Calculator

Work out hormone replacement dose instantly with clear inputs, formula shown and shareable results.

About Hormone Replacement Dose Calculator

Converts between oestrogen preparations using the widely quoted standard-dose equivalences of 1 mg oral estradiol, a 50 mcg/day patch and 0.625 mg conjugated oestrogens.

Formula

Standard-dose equivalence

1 mg/day oral estradiol is approximately equivalent to a 50 mcg/day transdermal patch, 0.625 mg/day conjugated equine oestrogens or 1 mg/day estradiol gel

Worked example

With the default values below, Hormone Replacement Dose Calculator returns Approximate equivalent dose of 50.000. Change any input above and every figure here is recalculated in your browser.

Inputs used

Current preparationone of Oral estradiol (mg/day), Transdermal estradiol patch (mcg/day), Conjugated equine oestrogens (mg/day), Estradiol gel (mg/day): Oral estradiol (mg/day)
Current doseaccepts 0.05–200: 1
Convert toone of Oral estradiol (mg/day), Transdermal estradiol patch (mcg/day), Conjugated equine oestrogens (mg/day), Estradiol gel (mg/day): Transdermal estradiol patch (mcg/day)

Results

Approximate equivalent dose: 50.000
Multiple of a standard dose: 1.00
Conversion ratio: 50.0000

Step by step

1Values used
2Standard-dose equivalence
3Approximate equivalent dose= 50.000
4Multiple of a standard dose= 1.00
5Conversion ratio= 50.0000

Assumptions and limits

The result is derived only from the 3 inputs listed above. Anything not among them is not part of the calculation.
In particular, this calculator does not take inflation, tax, fees or charges or compounding frequency into account.
Figures are rounded for display to 4 decimal places, so totals built from several rounded parts can differ slightly from the unrounded arithmetic.
Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.
This is an estimate for general information and not professional medical advice. See the full disclaimer for the limits that apply to this kind of calculator.

How these calculators are built and tested is described on the Methodology page. If a figure looks wrong, please report it.

Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.

Frequently Asked Questions

Are the routes clinically interchangeable?

Not entirely. Transdermal delivery avoids first-pass metabolism and carries a lower venous thromboembolism risk.

Is progestogen needed too?

Anyone with an intact uterus needs endometrial protection with a progestogen or a levonorgestrel intrauterine system.