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Divides an intravenous dose by the extrapolated zero-time concentration to give the apparent volume of distribution.
Volume of distribution
Vd = dose / concentration at time zero; Vd per kg = Vd / body weight
Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.
It is the volume that would be needed if the drug were evenly distributed at the plasma concentration, which is rarely physically true.
Yes. Drugs that concentrate in tissue, such as digoxin or chloroquine, have volumes of hundreds of litres.