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Area Under Curve (Drug) Calculator

Work out area under curve (drug) instantly with clear inputs, formula shown and shareable results.

About Area Under Curve (Drug) Calculator

Derives area under the curve from dose, bioavailability and clearance, and scales it to a 24-hour exposure for AUC-guided dosing.

Formula

AUC from clearance

AUC per interval = dose x bioavailability / clearance; AUC24 = AUC per interval x (24 / interval); average concentration = AUC / interval

Worked example

With the default values below, Area Under Curve (Drug) Calculator returns AUC over 24 hours of 400.00. Change any input above and every figure here is recalculated in your browser.

Inputs used

Dose per intervalaccepts 0.1–100,000 mg
1,000 mg
Clearanceaccepts 0.05–200 L/h
5 L/h
Bioavailabilityaccepts 5–100
100
Dosing intervalaccepts 1–72 h
12 h

Results

AUC over 24 hours
400.00 mg.h/L
AUC per dosing interval
200.00 mg.h/L
Average steady-state concentration
16.667 mg/L

Step by step

  1. 1Values used
  2. 2AUC from clearance
  3. 3AUC over 24 hours= 400.00 mg.h/L
  4. 4AUC per dosing interval= 200.00 mg.h/L
  5. 5Average steady-state concentration= 16.667 mg/L

Assumptions and limits

  • The result is derived only from the 4 inputs listed above. Anything not among them is not part of the calculation.
  • In particular, this calculator does not take inflation, tax, fees or charges or compounding frequency into account.
  • Figures are rounded for display to 3 decimal places, so totals built from several rounded parts can differ slightly from the unrounded arithmetic.
  • Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.

How these calculators are built and tested is described on the Methodology page. If a figure looks wrong, please report it.

Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.

Frequently Asked Questions

Why is AUC24 used for vancomycin?

AUC24 to MIC ratio predicts efficacy and nephrotoxicity better than trough concentrations alone.

Does AUC depend on the interval?

Total daily AUC depends only on daily dose and clearance; the interval changes the peaks and troughs, not the area.

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