Work out area under curve (drug) instantly with clear inputs, formula shown and shareable results.
Derives area under the curve from dose, bioavailability and clearance, and scales it to a 24-hour exposure for AUC-guided dosing.
AUC from clearance
AUC per interval = dose x bioavailability / clearance; AUC24 = AUC per interval x (24 / interval); average concentration = AUC / interval
Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.
AUC24 to MIC ratio predicts efficacy and nephrotoxicity better than trough concentrations alone.
Total daily AUC depends only on daily dose and clearance; the interval changes the peaks and troughs, not the area.