Work out drug clearance instantly with clear inputs, formula shown and shareable results.
Derives clearance from dose, bioavailability and area under the concentration-time curve, then converts it into a half-life using the volume of distribution.
Clearance
CL = dose x bioavailability / AUC; half-life = 0.693 x volume of distribution / clearance
Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.
The volume of plasma completely cleared of drug per unit time, not the amount removed.
Yes. Total clearance is the sum of renal, hepatic and other routes.