Skip to content
ENExplore Calculators

Drug Clearance Calculator

Work out drug clearance instantly with clear inputs, formula shown and shareable results.

About Drug Clearance Calculator

Derives clearance from dose, bioavailability and area under the concentration-time curve, then converts it into a half-life using the volume of distribution.

Formula

Clearance

CL = dose x bioavailability / AUC; half-life = 0.693 x volume of distribution / clearance

Worked example

With the default values below, Drug Clearance Calculator returns Clearance of 10.000. Change any input above and every figure here is recalculated in your browser.

Inputs used

Dose administeredaccepts 0.1–100,000 mg
500 mg
Area under the curveaccepts 0.1–10,000 mg.h/L
50 mg.h/L
Bioavailabilityaccepts 5–100
100
Volume of distributionaccepts 0.5–1,000 L
40 L

Results

Clearance
10.000 L/h
Clearance
166.67 mL/min
Implied half-life
2.77 h

Step by step

  1. 1Values used
  2. 2Clearance
  3. 3Clearance= 10.000 L/h
  4. 4Clearance= 166.67 mL/min
  5. 5Implied half-life= 2.77 h

Assumptions and limits

  • The result is derived only from the 4 inputs listed above. Anything not among them is not part of the calculation.
  • In particular, this calculator does not take inflation, tax, fees or charges or compounding frequency into account.
  • Figures are rounded for display to 3 decimal places, so totals built from several rounded parts can differ slightly from the unrounded arithmetic.
  • Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.

How these calculators are built and tested is described on the Methodology page. If a figure looks wrong, please report it.

Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.

Frequently Asked Questions

What does clearance actually measure?

The volume of plasma completely cleared of drug per unit time, not the amount removed.

Is clearance additive?

Yes. Total clearance is the sum of renal, hepatic and other routes.

Related Calculators

Drug Clearance Calculator – Calculate Clearance & Clearance