Work out maintenance dose instantly with clear inputs, formula shown and shareable results.
Multiplies clearance, target concentration and dosing interval, then divides by bioavailability, which is the standard maintenance dose relationship.
Maintenance dose
Dose = clearance (L/h) x target concentration (mg/L) x interval (h) / bioavailability; continuous infusion rate = clearance x target concentration
Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.
At steady state the rate in must equal the rate out, and the rate out is clearance times concentration.
Clearance falls, so either the dose is reduced or the interval lengthened to keep the same average concentration.