Work out peak and trough levels instantly with clear inputs, formula shown and shareable results.
Applies the one-compartment multiple-dose equations to predict steady-state peak and trough concentrations for a given dose and interval.
Multiple-dose peak and trough
ke = ln2 / half-life; Cmax = (dose / Vd) / (1 - e^-ke.tau); Cmin = Cmax x e^-ke.tau; accumulation factor = 1 / (1 - e^-ke.tau)
Educational estimate only. Not a substitute for professional clinical judgement, and must not be used to make treatment or dosing decisions.
Immediately before the next dose, once steady state has been reached.
Distribution is still occurring; peaks are usually drawn one to two hours after the infusion ends.